Department of Nutrition, University of Nevada, Reno, Nevada 89557-0208, USA.
Nutrients. 2010 Jul;2(7):725-36. doi: 10.3390/nu2070725. Epub 2010 Jul 7.
In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
除了表现出抗氧化特性外，共轭亚油酸（CLA）和维生素 E 还可能调节内源性抗氧化酶的基因表达。根据细胞的微环境，这种调节既可以反映出抗氧化作用，也可以反映出促氧化作用的结果。尽管流行病学/实验研究表明 CLA 和维生素 E 具有促进健康的特性，但最近的临床试验结果尚无定论。前瞻性研究和最近临床试验的结果之间存在差异，这可能归因于细胞微环境随浓度变化而发生改变。我们从这些亲脂性化合物的可能作用机制的角度出发，探讨了它们在活性氧（ROS）相关疾病干预中的应用。
