Zubenko G S, Brenner R P, Teply I
Department of Psychiatry, University of Pittsburgh School of Medicine 15213.
Stroke. 1991 Aug;22(8):997-1003. doi: 10.1161/01.str.22.8.997.
We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease.
我们之前曾报道，血小板膜流动性增加可识别出一组阿尔茨海默病患者，他们具有独特的临床特征，包括症状出现的年龄较早、认知衰退进展更快，以及局灶性脑电图检查结果的患病率降低。在当前研究中，与血小板膜流动性正常的患者相比，这些患者中风危险因素的患病率也较低。我们的研究结果表明，血小板膜异常描述了一组阿尔茨海默病患者的临床亚组，与符合可能阿尔茨海默病临床共识标准的其余患者相比，他们合并脑血管疾病的可能性较小。
