Zubenko G S, Huff F J, Beyer J, Auerbach J, Teply I
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.
Arch Gen Psychiatry. 1988 Oct;45(10):889-93. doi: 10.1001/archpsyc.1988.01800340011001.
Increased platelet membrane fluidity is a stable familial trait that identifies a prominent subgroup of patients with Alzheimer's disease. Patients in this subgroup have distinct clinical features, including an early age at symptomatic onset and a rapidly progressive course. The morbid risk of Alzheimer's-type dementia was studied in 421 first-degree relatives of 43 patients who met current consensus criteria for probable Alzheimer's disease and 47 healthy controls. Relatives of patients showed an approximate 50% (90- to 95-year) lifetime risk of dementia, regardless of the platelet membrane phenotype of the respective proband, which was over four times the control value. However, relatives of patients with increased platelet membrane fluidity who developed dementia exhibited symptoms significantly earlier than relatives of patients with normal platelet membrane fluidity. Alternative genetic models that describe the relationship of platelet membrane fluidity and Alzheimer's disease are discussed.
血小板膜流动性增加是一种稳定的家族性特征，它可识别出阿尔茨海默病患者中的一个显著亚组。该亚组患者具有独特的临床特征，包括症状出现的年龄较早以及病程进展迅速。对43名符合目前可能阿尔茨海默病共识标准的患者的421名一级亲属和47名健康对照者进行了阿尔茨海默型痴呆的发病风险研究。患者的亲属显示出约50%（90至95岁）的痴呆终生风险，无论各自先证者的血小板膜表型如何，这一风险是对照组的四倍多。然而，血小板膜流动性增加且患痴呆的患者亲属出现症状的时间明显早于血小板膜流动性正常的患者亲属。文中讨论了描述血小板膜流动性与阿尔茨海默病关系的替代遗传模型。
