Zubenko G S, Brenner R P, Teply I
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213.
Arch Neurol. 1988 Sep;45(9):1009-13. doi: 10.1001/archneur.1988.00520330099016.
Increased platelet membrane fluidity is a stable, familial characteristic that describes a clinically distinct subgroup of patients with Alzheimer's disease. In the current study, electroencephalograms (EEGs) from 49 patients with probable Alzheimer's disease were subjected to visual and computerized spectral analysis. Only three (14.3%) of 21 patients in the subgroup with increased platelet membrane fluidity exhibited focal EEG abnormalities, while 12 (42.9%) of 28 of the residual subgroup exhibited focal EEG findings, a threefold difference. This difference in EEG profile provides further validation of these two subgroups and suggests that the subgroup with increased fluidity is less heterogeneous than the residual group.
血小板膜流动性增加是一种稳定的家族性特征，它描述了阿尔茨海默病患者中一个临床上独特的亚组。在当前研究中，对49例可能患有阿尔茨海默病的患者的脑电图（EEG）进行了视觉和计算机化频谱分析。血小板膜流动性增加的亚组中的21例患者中只有3例（14.3%）表现出局灶性EEG异常，而其余亚组的28例中有12例（42.9%）表现出局灶性EEG结果，相差三倍。EEG特征的这种差异进一步证实了这两个亚组，并表明流动性增加的亚组比其余组的异质性更低。
