丝裂原活化蛋白激酶（MAPKs）的复杂性简化了。
The complexity of mitogen-activated protein kinases (MAPKs) made simple.
作者信息
Krishna M, Narang H
机构信息
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
出版信息
Cell Mol Life Sci. 2008 Nov;65(22):3525-44. doi: 10.1007/s00018-008-8170-7.
Abstract
The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various processes of growth, differentiation and cell death. In spite of their ubiquitous presence and seemingly enormous cross-talk with each other, their action is very specific. This review deals with various aspects of the three different MAPK pathways (ERK, p38 and JNK) and how their specificity is brought about.
摘要
已知丝裂原活化蛋白激酶（MAPK）通路参与生长、分化和细胞死亡的各种过程。尽管它们普遍存在且彼此之间似乎存在大量相互作用，但其作用却非常具有特异性。本综述探讨了三种不同的MAPK通路（ERK、p38和JNK）的各个方面以及它们的特异性是如何产生的。
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