Islam Md Shahidul, Choi Haymie
Department of Food and Nutrition, Seoul National University, Seoul 151-742, South Korea.
Phytother Res. 2008 Aug;22(8):1025-9. doi: 10.1002/ptr.2417.
The present study was conducted to clarify whether a low or a high, but tolerable, dietary dose of red chilli (RC) can ameliorate the diabetes related complications in a high-fat (HF) diet-fed streptozotocin (STZ)-induced type 2 diabetes model of rats. Five-week-old male Sprague Dawley rats were fed a HF diet for 2 weeks then randomly divided into four groups namely: normal control (NC), diabetic control (DBC), red chilli low (RCL, 0.5%) and red chilli high (RCH, 2.0%) groups. Diabetes was induced by an intraperitoneal (i.p.) injection of STZ (40 mg/kg BW) in all groups except the NC group. After 4 weeks feeding of experimental diets, the fasting blood glucose concentrations in both RC fed groups were not significantly different. The serum insulin concentration was significantly (p < 0.05) increased in the RCH group compared with the DBC and RCL groups. Blood HbA1c, liver weight, liver glycogen and serum lipids were not influenced by the feeding of RC-containing diets. The data of this study suggest that 2% dietary RC is insulinotropic rather than hypoglycemic at least in this experimental condition.
本研究旨在阐明低剂量或高剂量但可耐受的红辣椒（RC）饮食是否能改善高脂（HF）饮食喂养的链脲佐菌素（STZ）诱导的大鼠2型糖尿病模型中与糖尿病相关的并发症。将5周龄雄性Sprague Dawley大鼠喂食高脂饮食2周，然后随机分为四组，即：正常对照组（NC）、糖尿病对照组（DBC）、低剂量红辣椒组（RCL，0.5%）和高剂量红辣椒组（RCH，2.0%）。除NC组外，所有组均通过腹腔注射STZ（40mg/kg体重）诱导糖尿病。在喂食实验饮食4周后，两个红辣椒喂养组的空腹血糖浓度无显著差异。与DBC组和RCL组相比，RCH组的血清胰岛素浓度显著升高（p<0.05）。含红辣椒饮食的喂养对血液糖化血红蛋白、肝脏重量、肝糖原和血脂没有影响。本研究数据表明，至少在本实验条件下，2%的红辣椒饮食具有促胰岛素分泌作用而非降血糖作用。
