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特发性自身免疫性血小板减少性紫癜患者的循环免疫复合物与中性粒细胞吞噬功能

[Circulating immune complexes and neutrophilic phagocytic function in patients with idiopathic autoimmune thrombocytopenic purpura].

作者信息

Tishchenko L M, Volobueva Z V

出版信息

Vrach Delo. 1991 May(5):80-3.

PMID:1866927
Abstract

The concentration of circulating immune complexes, serum immunoglobulins and state of phagocytic function of neutrophils was studied in patients with autoimmune thrombocytopenic purpura. The patients showed a significant increase of the levels of circulating immune complexes, content of Ig M and Ig G, an increase of the phagocytic activity of neutrophils at the stage of migration, adhesion and absorption of the heterogeneous. The revealed disorders of phagocytic function and destruction of granulocytes at the stage of digestion may be explained by increased load on the phagocytic neutrophils due to the main pathologic process.

摘要

对自身免疫性血小板减少性紫癜患者的循环免疫复合物浓度、血清免疫球蛋白及中性粒细胞吞噬功能状态进行了研究。患者循环免疫复合物水平、IgM和IgG含量显著升高,中性粒细胞在迁移、黏附及吞噬异质物阶段的吞噬活性增强。所发现的吞噬功能紊乱及消化阶段粒细胞的破坏,可能是由于主要病理过程导致吞噬性中性粒细胞负荷增加所致。

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