Kurata Y, Hayashi S, Aochi H, Nagamine K, Oshida M, Mizutani H, Tomiyama Y, Tsubakio T, Yonezawa T, Tarui S
Clin Exp Immunol. 1987 Feb;67(2):293-9.
Circulating immune complexes (CIC) were frequently observed in patients with idiopathic thrombocytopenic purpura (ITP). To analyse the pathogenic role of CIC, we studied the correlation between the disease activity and the CIC level, and whether platelet antigens were involved in CIC from ITP sera. Elevated CIC levels, measured by Clq, anti-C3 and spermatozoa micro-enzyme-linked immunosorbent assay, were found in 37%, 54% and 52% of the patients, respectively. However, there were no significant correlations (r = -0.11, -0.03 and -0.04, respectively) between the platelet count and the CIC level. Platelet antigens in CIC were detected with rabbit anti-human platelet serum. The CIC from 18%, 25% and 25%, respectively, of ITP sera contained platelet antigens, but the CIC from only 3%, 9% and 6% of SLE sera and from 3%, 2% and 5% of the sera of alloimmunized patients, respectively, contained these antigens. There were significant correlations (r = 0.51, 0.80 and 0.65, respectively) between the amount of platelet antigens and the CIC level in ITP sera. However, there were no correlations (r = -0.26, -0.29 and 0.08, respectively) between the platelet count and the amount of platelet antigens in the CIC. We detected platelet antigens in CIC from ITP sera, but surmise that these CIC perhaps do not play an important role in platelet destruction.
特发性血小板减少性紫癜（ITP）患者中经常观察到循环免疫复合物（CIC）。为了分析CIC的致病作用，我们研究了疾病活动度与CIC水平之间的相关性，以及血小板抗原是否参与ITP血清中的CIC。通过Clq、抗C3和精子微酶联免疫吸附测定法测得，分别有37%、54%和52%的患者CIC水平升高。然而，血小板计数与CIC水平之间无显著相关性（分别为r = -0.11、-0.03和-0.04）。用兔抗人血小板血清检测CIC中的血小板抗原。分别有18%、25%和25%的ITP血清中的CIC含有血小板抗原，但系统性红斑狼疮（SLE）血清中只有3%、9%和6%的CIC含有这些抗原，同种免疫患者血清中分别只有3%、2%和5%的CIC含有这些抗原。ITP血清中血小板抗原量与CIC水平之间存在显著相关性（分别为r = 0.51、0.80和0.65）。然而，血小板计数与CIC中血小板抗原量之间无相关性（分别为r = -0.26、-0.29和0.08）。我们在ITP血清的CIC中检测到了血小板抗原，但推测这些CIC可能在血小板破坏中不发挥重要作用。
