Dukhin A I
Vestn Akad Med Nauk SSSR. 1991(4):8-11.
The paper presents the findings on the functional activity of specific antibody-forming cells (AFC) in the time-course of the primary influenza infection in mice. The concept of AFC functional activity is validated. Studying of the AFC population in the pool of splenocytes based on the analysis of functional activity permitted one to make a detailed description of specific AFC, and make a series of conclusions of the technique of AFC identification, reveal the changes in the structure of the virus-specific AFC population under the influenza infection which are not related to their quantity. Principle difference was revealed in the time-course of AFC functional activity in various patterns of influenza. Continuous changes in the AFC structure were observed during the whole period of observation.
本文介绍了在小鼠原发性流感感染过程中特定抗体形成细胞（AFC）功能活性的研究结果。AFC功能活性的概念得到了验证。基于功能活性分析对脾细胞池中的AFC群体进行研究，使得能够对特定AFC进行详细描述，并就AFC鉴定技术得出一系列结论，揭示流感感染下病毒特异性AFC群体结构的变化，这些变化与其数量无关。在不同流感模式下AFC功能活性的时间进程中发现了主要差异。在整个观察期间均观察到AFC结构的持续变化。
