丙戊酸盐与扑米酮作为添加药物治疗卡马西平反应不佳的部分性癫痫患者的比较。
Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy.
作者信息
Sun Mei Zhen, Deckers Charles L P, Liu Yu Xi, Wang Wei
机构信息
Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China.
出版信息
Seizure. 2009 Mar;18(2):90-3. doi: 10.1016/j.seizure.2008.06.009. Epub 2008 Jul 30.
PURPOSE
Evaluation of the efficacy of add-on valproate (VPA) or primidone (PRM) in patients with partial epilepsy unresponsive to carbamazepine (CBZ).
METHODS
The trial was prospective and open. Patients, aged 8-58 years, with partial epilepsy who did not become seizure free on CBZ were randomized to either VPA add-on or PRM add-on. The baseline period and the evaluation period were both 3 months. Proportions of patients with different degrees of reduction in seizure frequency were determined.
RESULTS
Significantly more patients on VPA (51% of 68 patients) achieved a greater than 50% seizure reduction than on PRM (34% of 68 patients). There was no significant difference in percentage seizure free (26% and 16%, respectively) or in percentage treatment withdrawals due to adverse effects.
CONCLUSION
Our results indicated that the efficacy of the CBZ/VPA combination tends to be greater than the efficacy of the CBZ/PRM combination.
目的
评估在对卡马西平（CBZ）无反应的部分性癫痫患者中加用丙戊酸盐（VPA）或扑米酮（PRM）的疗效。
方法
该试验为前瞻性开放性试验。年龄在8至58岁之间、患有部分性癫痫且使用CBZ后仍未实现无癫痫发作的患者被随机分为加用VPA组或加用PRM组。基线期和评估期均为3个月。确定癫痫发作频率不同程度降低的患者比例。
结果
使用VPA的患者（68例患者中的51%）癫痫发作减少超过50%的比例显著高于使用PRM的患者（68例患者中的34%）。无癫痫发作的百分比（分别为26%和16%）或因不良反应而停药的百分比无显著差异。
结论
我们的结果表明，CBZ/VPA联合用药的疗效往往大于CBZ/PRM联合用药的疗效。
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