Duke B O, Zea-Flores G, Castro J, Cupp E W, Munoz B
American Registry of Pathology, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, DC.
Am J Trop Med Hyg. 1991 Jul;45(1):132-7. doi: 10.4269/ajtmh.1991.45.132.
Adult Onchocerca volvulus worms, extracted from nodules of Guatemalans by collagenase digestion, were examined whole and by histological techniques. One group of persons received a single 150 micrograms/kg dose of ivermectin; two other groups (one with older and one with younger nodules) received four similar doses of ivermectin at 6-month intervals. For each group, there were comparable untreated controls. All nodules were removed six months after the last dose. After a single dose, the only significant difference from the controls was in the decreased proportion of female worms producing live microfilariae. After four doses, there were significant increases in the proportions of moribund/dead female worms and of live uninseminated females, when compared with the corresponding controls. There were also fewer male worms present, but this difference was not significant. Six months after the conclusion of the 4-dose regimen, the proportion of female worms producing live microfilariae was significantly lower than in the groups that had received a single dose.
从危地马拉人结节中通过胶原酶消化提取的成年盘尾丝虫，进行了整体检查和组织学技术检查。一组人接受了150微克/千克的单剂量伊维菌素；另外两组（一组结节较老，一组结节较年轻）每隔6个月接受四次类似剂量的伊维菌素。每组都有相应的未治疗对照组。在最后一剂后的六个月，所有结节都被移除。单剂量后，与对照组相比，唯一显著的差异是产生活微丝蚴的雌虫比例降低。四次剂量后，与相应对照组相比，濒死/死亡雌虫和活未受精雌虫的比例显著增加。雄虫数量也较少，但这种差异不显著。在4剂疗程结束6个月后，产生活微丝蚴的雌虫比例显著低于接受单剂量的组。
