Adan Ana, Prat Gemma, Fabbri Marco, Sànchez-Turet Miquel
Department of Psychiatry and Clinical Psychobiology, School of Psychology, University of Barcelona, Passeig Vall d'Hebron 171, 08035 Barcelona, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1698-703. doi: 10.1016/j.pnpbp.2008.07.005. Epub 2008 Jul 15.
Some previous studies have demonstrated an early effect of caffeine administration on subjective state, but none of them has explored its existence after the administration of decaffeinated coffee, or the possible differences depending on the gender and circadian typology of the subjects. The aim of the present work is to investigate the early effects (10-30 min post-consumption) of a single low dose of caffeine (100 mg) and decaffeinated coffee on sleepiness, subjective activation and affect using a realistic design. The influence of gender and circadian typology is also explored.
A randomized double-blind informed placebo controlled procedure was applied to 688 healthy undergraduate volunteers, mean age 22.03+/-2.21 years, 238 men and 450 women. Measures were recorded before and after beverage consumption (10, 20 and 30 min), in two experimental sessions: morning 11:00-13:00 h or afternoon 16:00-18:00 h.
Caffeine administration induced arousing effects (lesser somnolence and greater activation) in all post-consumption records, while the effects of decaffeinated drink were only apparent at 10 min. Caffeine effects were greater in men, and the decaffeinated beverage produced greater effects in women. Circadian typology only showed effects for time of day (morning/afternoon) related with rhythmic expression.
Future works should study more accurately the early effect of coffee beverages and the influence of gender, using other parameters which have proven to be sensitive to their administration. The effect of several caffeine doses should also be studied.
先前的一些研究已证明摄入咖啡因对主观状态有早期影响,但均未探讨脱咖啡因咖啡摄入后的这种影响,或根据受试者的性别和昼夜节律类型可能存在的差异。本研究的目的是采用实际可行的设计,调查单次低剂量咖啡因(100毫克)和脱咖啡因咖啡对嗜睡、主观激活和情感的早期影响(饮用后10 - 30分钟)。同时也探讨性别和昼夜节律类型的影响。
对688名健康的本科志愿者(平均年龄22.03±2.21岁,男性238名,女性450名)采用随机双盲知情安慰剂对照程序。在两个实验时段(上午11:00 - 13:00或下午16:00 - 18:00),分别在饮用饮料前及饮用后(10、20和30分钟)记录各项指标。
摄入咖啡因在饮用后的所有记录中均引起兴奋作用(嗜睡减轻、激活增强),而脱咖啡因饮料的作用仅在10分钟时明显。咖啡因对男性的作用更大, 脱咖啡因饮料对女性的作用更大。昼夜节律类型仅显示出与节律表达相关的一天中不同时间(上午/下午)的影响。
未来的研究应更准确地研究咖啡饮料的早期影响以及性别的影响,使用已证明对其摄入敏感的其他参数。还应研究几种咖啡因剂量的影响。