Hibbs J, Perper J, Winek C L
Division of Field Services, Centers for Disease Control, Atlanta, Ga.
JAMA. 1991 Feb 27;265(8):1011-3. doi: 10.1001/jama.265.8.1011.
3-Methylfentanyl ("China White") is a "designer" opiate that has caused more than 100 overdose deaths in California since 1979, but that has not been associated previously with deaths east of the Rocky Mountains. During 1988, 3-methylfentanyl was identified in 16 fatal overdose cases in Allegheny County, Pennsylvania, contributing to a fourfold rise in overdose mortality during October of that year. Morphine was detected in the blood of five persons (31%) and cocaine in the blood of three persons (19%) dying of 3-methylfentanyl overdoses; these were demographically similar to 99 other fatal overdose cases investigated by the county coroner from 1986 through 1988. This documents the contribution of 3-methylfentanyl to overdose mortality in an eastern city and the use of 3-methylfentanyl with other illegal drugs. Drug abusers in the northeastern United States should be considered at risk for more "designer drug" overdose outbreaks in the future.
3-甲基芬太尼（“中国白”）是一种“设计型”阿片类药物，自1979年以来已在加利福尼亚州导致100多人过量用药死亡，但此前在落基山脉以东地区并未出现过与死亡相关的案例。1988年期间，在宾夕法尼亚州阿勒格尼县的16起致命过量用药案例中发现了3-甲基芬太尼，导致该年10月过量用药死亡率增长了四倍。在死于3-甲基芬太尼过量的五人（31%）血液中检测出吗啡，三人（19%）血液中检测出可卡因；这些人与该县验尸官在1986年至1988年期间调查的其他99起致命过量用药案例在人口统计学特征上相似。这证明了3-甲基芬太尼对东部一个城市过量用药死亡率的影响以及3-甲基芬太尼与其他非法药物的联用情况。美国东北部的药物滥用者未来应被视为有更多“设计型药物”过量用药事件爆发的风险人群。
