Snead Malcolm L
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, CA, USA.
J Dent Educ. 2008 Aug;72(8):903-11.
A team of senior scientists was formed in 2006 to create a blueprint for the regeneration of whole human teeth along with all of the supporting structure of the dentition. The team included experts from diverse fields, each with a reputation for stellar accomplishment. Participants attacked the scientific issues of tooth regeneration but, more importantly, each agreed to work collaboratively with experts from other disciplines to form a learning organization. A commitment to learn from one another produced a unique interdisciplinary and multidisciplinary team. Inspired by the Kennedy space program to send a man to the moon, with its myriad of problems and solutions that no one discipline could solve, this tooth regeneration team devised an ambitious plan that sought to use stem cell biology, engineering, and computational biology to replicate the developmental program for odontogenesis. In this manner, team members envisioned a solution that consisted of known or knowable fundamentals. They proposed a laboratory-grown tooth rudiment that would be capable of executing the complete program for odontogenesis when transplanted to a suitable host, recreating all of the dental tissues, periodontal ligament, cementum, and alveolar bone associated with the canonical tooth. This plan was designed to bring regenerative medicine fully into the dental surgery suite, although a lack of funding has so far prevented the plan from being carried out.
2006年，一个资深科学家团队成立，旨在为整颗人类牙齿以及牙列的所有支持结构的再生制定蓝图。该团队成员来自不同领域，每个人都以卓越成就而闻名。参与者们着手解决牙齿再生的科学问题，但更重要的是，每个人都同意与其他学科的专家合作，形成一个学习型组织。相互学习的承诺造就了一个独特的跨学科和多学科团队。受肯尼迪太空计划将人类送上月球的启发，该计划面临着无数单一学科无法解决的问题和解决方案，这个牙齿再生团队制定了一个雄心勃勃的计划，试图利用干细胞生物学、工程学和计算生物学来复制牙齿发育程序。通过这种方式，团队成员设想了一个由已知或可知的基本原理组成的解决方案。他们提出了一种实验室培育的牙齿原基，当移植到合适的宿主中时，它能够执行完整的牙齿发育程序，重新生成与标准牙齿相关的所有牙齿组织、牙周韧带、牙骨质和牙槽骨。尽管目前资金短缺阻碍了该计划的实施，但该计划旨在将再生医学全面引入牙科手术室。
