Steindorff Marina M, Lehl Helena, Winkel Andreas, Stiesch Meike
Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School (MHH), 30625 Hannover, Germany.
Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School (MHH), 30625 Hannover, Germany.
Arch Oral Biol. 2014 Feb;59(2):158-66. doi: 10.1016/j.archoralbio.2013.11.005. Epub 2013 Nov 18.
In recent years, scientists in almost every medical sector moved the focus to tissue transplantation and stem cell-based therapies for organ and tissue regeneration. In dentistry, it is of great interest in this regard to restore natural teeth with the help of stem cell-based regeneration of soft tissues and hard tooth structures. Many studies have been published in which structures resembling teeth were constructed using stem cells. In most of these studies, carrier materials (scaffolds) were used, which were colonized with cells and then implanted into an animal. Apart from this, scaffold-free approaches based on cell aggregation have also been published. Although animal studies on tooth regeneration have been very promising, much more research is needed until this can be applied in human.
近年来，几乎每个医学领域的科学家都将重点转向了组织移植和基于干细胞的器官与组织再生疗法。在牙科领域，借助基于干细胞的软组织和硬牙结构再生来修复天然牙齿在这方面备受关注。已经发表了许多研究，其中利用干细胞构建了类似牙齿的结构。在大多数这些研究中，使用了载体材料（支架），将细胞接种在上面，然后植入动物体内。除此之外，基于细胞聚集的无支架方法也已发表。尽管关于牙齿再生的动物研究前景十分广阔，但在其能够应用于人类之前，还需要进行更多的研究。
