Berg Thorsten
Max Planck Institute of Biochemistry, Department of Molecular Biology, Am Klopferspitz 18, 82152 Martinsried, Germany.
Chembiochem. 2008 Sep 1;9(13):2039-44. doi: 10.1002/cbic.200800274.
Signal transducers and activators of transcription (STATs) are a family of transcription factors that are of central importance for cellular signaling and have therefore emerged as attractive target proteins for cell-permeable small molecules. This review outlines the basic concept of STAT signaling, the relevance of individual members of the STAT family for cellular signaling and human disease, and generally applicable approaches taken to the identification of small-molecule inhibitors of STATs.
信号转导子和转录激活子（STATs）是一类转录因子，对细胞信号传导至关重要，因此已成为细胞可渗透小分子的有吸引力的靶蛋白。本综述概述了STAT信号传导的基本概念、STAT家族各个成员在细胞信号传导和人类疾病中的相关性，以及用于鉴定STAT小分子抑制剂的通用方法。
