Ates Orhan, Keles Mustafa, Bilen Habip, Kiziltunc Ahmet, Kocer Ibrahim, Kulacoglu Destan Nil, Türkeli Mehmet, Baykal Orhan
Department of Ophthalmology, Medical Faculty, Ataturk University, Erzurum, Turkey.
Tohoku J Exp Med. 2008 Aug;215(4):373-6. doi: 10.1620/tjem.215.373.
Retinal vein occlusion is an important cause of visual loss. Several ocular and systemic conditions have been reported for retinal vein occlusion. The pathogenesis of thrombus formation in the retinal vein, which results in retinal vein occlusion, is unclear. The aim of this study was to investigate the correlation between increased serum leptin levels and the occurrence of retinal vein occlusion (RVO). The study group consisted of 40 patients with RVO (58.1 +/- 6 years old; 17 males and 23 females): 15 patients with central RVO, 23 with branch RVO, and 2 with hemispheric RVO. The patients who had any ocular or systemic pathology were not included in the study. The control group consisted of 40 healthy individuals of similar gender, age, date and type of health survey, and geographic region. The blood samples of the RVO patients (n = 40) and controls (n = 40) were obtained antecubitally. Leptin levels were measured by an enzyme-linked immunosorbent assay (ELISA) method, and Student's t-test was used to determine differences between the groups. The mean serum leptin levels were 12.5 +/- 1.64 ng/ml in patients with RVO and 8.4 +/- 1.22 ng/ml in the control subjects; namely, the mean serum leptin levels were significantly higher in the patients with RVO (p < 0.001). These results suggest that leptin may be involved in the pathogenesis of venous thrombosis in the retina probably through its effects on homeostasis of the vessel wall.
视网膜静脉阻塞是视力丧失的一个重要原因。已有多项眼部和全身疾病与视网膜静脉阻塞相关的报道。导致视网膜静脉阻塞的视网膜静脉血栓形成的发病机制尚不清楚。本研究的目的是探讨血清瘦素水平升高与视网膜静脉阻塞（RVO）发生之间的相关性。研究组由40例RVO患者组成（年龄58.1±6岁；男性17例，女性23例）：15例中央型RVO患者，23例分支型RVO患者，2例半侧型RVO患者。患有任何眼部或全身疾病的患者均未纳入本研究。对照组由40名性别、年龄、健康调查日期和类型以及地理区域相似的健康个体组成。RVO患者（n = 40）和对照组（n = 40）的血样从前臂肘前静脉采集。采用酶联免疫吸附测定（ELISA）法测量瘦素水平，并使用学生t检验确定组间差异。RVO患者的平均血清瘦素水平为12.5±1.64 ng/ml，对照组为8.4±1.22 ng/ml；也就是说，RVO患者的平均血清瘦素水平显著更高（p < 0.001）。这些结果表明，瘦素可能通过其对血管壁内环境稳定的影响而参与视网膜静脉血栓形成的发病机制。
