血浆中五聚体蛋白3升高及其与视网膜静脉阻塞的关联。
Elevated plasma pentraxin 3 and its association with retinal vein occlusion.
作者信息
Park Kyung Soo, Kim Ji Wan, An Jae Hwan, Woo Je Moon
机构信息
Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
出版信息
Korean J Ophthalmol. 2014 Dec;28(6):460-5. doi: 10.3341/kjo.2014.28.6.460. Epub 2014 Nov 19.
PURPOSE
To evaluate plasma pentraxin 3 (PTX3) in patients with retinal vein occlusion (RVO), and investigate the possibility of its role as a predictive biomarker.
METHODS
Nested case-control study. The study included 57 patients with RVO and 45 age- and gender-matched subjects without RVO as controls. Plasma PTX3 and C-reactive protein concentration were measured in both groups a posteriori from frozen samples by using an enzyme-linked immunosorbent assay kit.
RESULTS
The measured PTX3 value for the RVO group was 1,508 ± 1,183 pg/mL (mean ± standard deviation) and 833 ± 422 pg/mL for the controls (p < 0.001). There was no significant difference in PTX3 levels between patients with central retinal vein occlusion and branched retinal vein occlusion (1,468 ± 1,300 vs. 1,533 ± 1,121 pg/mL; p = 0.818).
CONCLUSIONS
Our data seems to support the role of chronic inflammation and ischemia in the development of RVO. It is possible that PTX3 can be used as a diagnostic biomarker of RVO.
目的
评估视网膜静脉阻塞（RVO）患者的血浆五聚体3（PTX3），并探讨其作为预测生物标志物的可能性。
方法
巢式病例对照研究。该研究纳入了57例RVO患者和45例年龄及性别匹配的无RVO受试者作为对照。两组均使用酶联免疫吸附测定试剂盒，对冷冻样本事后测量血浆PTX3和C反应蛋白浓度。
结果
RVO组测得的PTX3值为1508±1183 pg/mL（平均值±标准差），对照组为833±422 pg/mL（p<0.001）。视网膜中央静脉阻塞患者和视网膜分支静脉阻塞患者的PTX3水平无显著差异（1468±1300 vs. 1533±1121 pg/mL；p = 0.818）。
结论
我们的数据似乎支持慢性炎症和缺血在RVO发生发展中的作用。PTX3有可能用作RVO的诊断生物标志物。
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