Pierik L T, Murphy E L
University of California, San Francisco.
AIDS Clin Rev. 1991:39-57.
Although early reports of an etiological role of HTLV-I in AIDS are not supported by subsequent epidemiologic and biologic data, all AIDS specialists should be aware of the possible infection of AIDS risk group members with the HTLV viruses. In the United States, HTLV-II and HIV co-exist in high prevalence among IVDU, and coinfected IVDU may progress more quickly to AIDS. The health effects of solitary HTLV-II infection are currently unknown. In Africa and the Caribbean, where HTLV-I is endemic, the epidemic of HIV infection will likewise produce coinfection and possibly faster progression to AIDS. In addition, adult T-cell leukemia/lymphoma and HTLV-associated myelopathy (HAM/TSP) may occur in persons infected with HTLV-I alone. Clinical care of HTLV infected patients is difficult because of societal confusion of these viruses with HIV. The full health effects of both HTLV-I and HTLV-II are not yet known, and even the two known disease outcomes of HTLV-I infection occur in only a few percent of those infected. Without prognostic indicators, and with the long latency from infection to disease, counseling and medical follow-up of patients is difficult. Further research into the clinical effects of HTLV-I and HTLV-II is urgently needed.
尽管人类嗜T淋巴细胞病毒I型（HTLV-I）在艾滋病病因学作用方面的早期报告未得到后续流行病学和生物学数据的支持，但所有艾滋病专家都应意识到艾滋病风险群体成员可能感染HTLV病毒。在美国，静脉注射毒品者（IVDU）中HTLV-II和HIV的共存率很高，同时感染这两种病毒的IVDU可能更快发展为艾滋病。目前尚不清楚单独感染HTLV-II对健康的影响。在HTLV-I流行的非洲和加勒比地区，HIV感染的流行同样会导致合并感染，并可能更快发展为艾滋病。此外，成人T细胞白血病/淋巴瘤和HTLV相关脊髓病（HAM/TSP）可能仅发生在单独感染HTLV-I的人群中。由于社会上对这些病毒与HIV的混淆，对HTLV感染患者的临床护理很困难。HTLV-I和HTLV-II对健康的全面影响尚不清楚，即使是HTLV-I感染已知的两种疾病结局也仅发生在少数感染者中。由于缺乏预后指标，且从感染到发病的潜伏期很长，对患者的咨询和医学随访很困难。迫切需要对HTLV-I和HTLV-II的临床影响进行进一步研究。
