HST/FGFK基因相对于11q13染色体断点和脆性位点的定位。
Localization of the HST/FGFK gene with regard to 11q13 chromosomal breakpoint and fragile site.
作者信息
Hagemeijer A, Lafage M, Mattei M G, Simonetti J, Smit E, de Lapeyriere O, Birnbaum D
机构信息
Erasmus University, Rotterdam, The Netherlands.
出版信息
Genes Chromosomes Cancer. 1991 May;3(3):210-4. doi: 10.1002/gcc.2870030307.
PMID:1868036
Abstract
The HST/FGFK gene, a member of the fibroblast growth factor gene family and a protooncogene, is localized on chromosomal band 11q13. Genes in this region are frequently involved in hematopoietic and solid tumors. Here we show that the HST gene lies telomeric to the BCL1 gene, the t(11;14)(q13;q32) breakpoint, and the FRA11A rare fragile site.
摘要
HST/FGFK基因是成纤维细胞生长因子基因家族的成员之一，也是一种原癌基因，定位于染色体11q13带。该区域的基因经常与血液系统肿瘤和实体瘤有关。在此我们表明，HST基因位于BCL1基因、t(11;14)(q13;q32)断裂点以及FRA11A罕见脆性位点的端粒侧。
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