定位FRA11A，人类染色体11q13.3带中的一个叶酸敏感脆性位点。

Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3.

作者信息

Perucca-Lostanlen D, Hecht B K, Courseaux A, Grosgeorge J, Hecht F, Gaudray P

机构信息

Instabilité et Altérations des Génomes, CNRS/UNSA UMR 6549, Nice, France.

出版信息

Cytogenet Cell Genet. 1997;79(1-2):88-91. doi: 10.1159/000134689.

DOI:10.1159/000134689

PMID:9533019

Abstract

FRA11A, a rare folate-sensitive fragile site assigned to 11q13.3, lies in an area of genomic instability associated with several diseases and amplification events. To map FRA11A, we used fluorescence in situ hybridization with yeast artificial chromosome and cosmid probes on metaphase chromosomes of patients expressing the fragile site. FRA11A was found situated centromeric to ACTN3 and telomeric to D11S913, these markers being within an interval of approximately 1 Mb in the 11q13.3 region.

摘要

FRA11A是一个罕见的叶酸敏感脆性位点，定位于11q13.3，位于与多种疾病和扩增事件相关的基因组不稳定区域。为了绘制FRA11A的图谱，我们使用酵母人工染色体和黏粒探针进行荧光原位杂交，对表达该脆性位点的患者中期染色体进行检测。发现FRA11A位于ACTN3的着丝粒侧和D11S913的端粒侧，这些标记位于11q13.3区域大约1 Mb的区间内。