耐大环内酯类宋内志贺菌
Macrolide-resistant Shigella sonnei.
作者信息
Boumghar-Bourtchai Leyla, Mariani-Kurkdjian Patricia, Bingen Edouard, Filliol Ingrid, Dhalluin Anne, Ifrane Shadia Ait, Weill François-Xavier, Leclercq Roland
机构信息
Centre Hospitalier Universitaire Côte de Nacre, Caen, France.
出版信息
Emerg Infect Dis. 2008 Aug;14(8):1297-9. doi: 10.3201/eid1408.080147.
Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2 -phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.
宋内志贺菌UCN59于2007年1月宋内志贺菌暴发期间分离得到，对阿奇霉素耐药（MIC为64mg/L）。该分离株含有一个携带mph(A)基因的质粒，该基因编码一种使大环内酯类药物失活的大环内酯2-磷酸转移酶。宋内志贺菌中mph(A)基因的出现可能会限制阿奇霉素在治疗志贺菌病中的应用。
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