Sobel J, Cameron D N, Ismail J, Strockbine N, Williams M, Diaz P S, Westley B, Rittmann M, DiCristina J, Ragazzoni H, Tauxe R V, Mintz E D
Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
J Infect Dis. 1998 May;177(5):1405-9. doi: 10.1086/517825.
During 1994-1996, Shigella sonnei outbreaks occurred in 8 North American traditionally observant Jewish communities. These communities remain relatively separate from neighboring populations while maintaining close contact by travel with coreligionists in other cities. Epidemiologic investigations suggested community-to-community transmission via travel. Outbreak-related and control isolates of S. sonnei from each city were subtyped by pulsed-field gel electrophoresis (PFGE) to confirm an epidemiologic linkage between outbreaks. Forty-three (94%) of 46 outbreak-related isolates had closely related PFGE patterns, constituting a single subtype; 33 (94%) of 35 control isolates demonstrated unrelated PFGE patterns. Several patterns differing by < or = 3 bands were identified within the outbreak subtype; one of these accounted for 65% of outbreak isolates. Hence, a single subtype of S. sonnei caused an international outbreak involving 8 traditionally observant Jewish communities, but not neighboring populations, over a 2-year period, suggesting sustained propagation of the epidemic strain between communities.
1994年至1996年期间，北美8个传统犹太教社区爆发了宋内志贺菌疫情。这些社区与周边人群相对隔离，但通过与其他城市的同宗教信徒旅行保持密切联系。流行病学调查表明，疫情通过旅行在社区间传播。对每个城市与疫情相关及对照的宋内志贺菌分离株进行脉冲场凝胶电泳（PFGE）分型，以确认疫情之间的流行病学关联。46株与疫情相关的分离株中有43株（94%）具有密切相关的PFGE图谱，构成单一亚型；35株对照分离株中有33株（94%）显示出不相关的PFGE图谱。在疫情亚型中鉴定出几种相差≤3条带的图谱；其中一种占疫情分离株的65%。因此，一种单一亚型的宋内志贺菌在两年时间内引发了一场涉及8个传统犹太教社区而非周边人群的国际疫情，表明该流行菌株在社区间持续传播。
