Cooper Curtis L
University of Ottawa Hospital, Division of Infectious Diseases, The Ottawa Hospital, Ottawa, Canada.
J Addict Dis. 2008;27(2):61-8. doi: 10.1300/J069v27n02_07.
Hepatitis C (HCV) infection in substance addicted patients is common and represents a therapeutically challenging co-morbidity. Alcohol and perhaps other substances of abuse directly influence the natural progression of HCV disease. Concurrent mental health illness, poor socioeconomic status, and unstructured life styles are often incompatible with safe and successful delivery of HCV treatment. These issues and their effect on treatment suitability and outcome are considered in this review. Funding for HCV-addiction research and strong political backing for interventions proven to benefit those struggling with addiction are paramount to increasing access to and uptake of HCV treatment. These interventions include substance cessation programs, safe injection settings to reduce HCV incidence and multidisciplinary teams to facilitate HCV treatment provision.
物质成瘾患者中的丙型肝炎病毒（HCV）感染很常见，是一种在治疗上具有挑战性的合并症。酒精以及其他可能的滥用物质会直接影响HCV疾病的自然进展。同时存在的心理健康问题、社会经济地位低下以及无规律的生活方式通常不利于安全、成功地进行HCV治疗。本综述探讨了这些问题及其对治疗适用性和结果的影响。为HCV成瘾研究提供资金以及对经证实对成瘾者有益的干预措施给予强有力的政治支持，对于增加HCV治疗的可及性和接受度至关重要。这些干预措施包括物质戒断项目、减少HCV感染率的安全注射场所，以及促进HCV治疗提供的多学科团队。
