丙型肝炎病毒感染与癌症风险：基于人群的队列研究。
Hepatitis C virus infection and risk of cancer: a population-based cohort study.
机构信息
Department of Infectious Diseases, Rigshospitalet, Denmark;
出版信息
Clin Epidemiol. 2010 Aug 9;2:179-86. doi: 10.2147/clep.s10193.
BACKGROUND
Hepatitis C virus (HCV) infection is associated with an increased risk of primary liver cancer; however, 5- and 10-year risk estimates are needed. The association of HCV with non-Hodgkin lymphoma (NHL) is uncertain and the association with other cancers is unknown.
METHOD
We conducted a nationwide, population-based cohort study of 4,349 HCV-infected patients in Denmark, computing standardized incidence ratios (SIR) of cancer incidence in HCV infected patients compared with cancer incidence of the general population. We calculated 5- and 10-year risks of developing cancer, stratifying our analyses based on the presence of HIV coinfection and cirrhosis.
RESULTS
WE RECORDED AN INCREASED RISK OF PRIMARY LIVER CANCER (SIR: 76.63 [95% CI: 51.69-109.40]), NHL (SIR: 1.89 [95% CI: 0.39-5.52]), and several smoking- and alcohol-related cancers in HCV infected patients without HIV coinfection. HCV-infected patients without HIV coinfection had a 6.3% (95% CI: 4.6%-8.7%) risk of developing cancer and 2.0% (95% CI: 1.1%-3.8%) risk of developing primary liver cancer within 10 years.
CONCLUSION
We confirmed the association of HCV infection with primary liver cancer and NHL. We also observed an association between HCV infection and alcohol- and smoking-related cancers.
背景
丙型肝炎病毒（HCV）感染与原发性肝癌的风险增加相关；然而，需要 5 年和 10 年的风险评估。HCV 与非霍奇金淋巴瘤（NHL）的相关性尚不确定，与其他癌症的相关性也未知。
方法
我们在丹麦进行了一项全国性的、基于人群的 HCV 感染患者队列研究，计算了 HCV 感染患者癌症发病率的标准化发病比（SIR），并与普通人群的癌症发病率进行比较。我们计算了发生癌症的 5 年和 10 年风险，分析基于 HIV 合并感染和肝硬化的存在进行分层。
结果
我们发现 HCV 感染患者（无 HIV 合并感染）发生原发性肝癌（SIR：76.63 [95% CI：51.69-109.40]）、非霍奇金淋巴瘤（SIR：1.89 [95% CI：0.39-5.52]）和几种与吸烟和饮酒相关的癌症的风险增加。无 HIV 合并感染的 HCV 感染患者发生癌症的风险为 6.3%（95% CI：4.6%-8.7%），10 年内发生原发性肝癌的风险为 2.0%（95% CI：1.1%-3.8%）。
结论
我们证实了 HCV 感染与原发性肝癌和 NHL 的相关性。我们还观察到 HCV 感染与酒精和吸烟相关癌症之间的关联。
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