Sriganeshan Vathany, Blom Thomas R, Weissmann David J
Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Arch Pathol Lab Med. 2008 Aug;132(8):1346-9. doi: 10.5858/2008-132-1346-AUCOMC.
Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with a poor prognosis that may be confused with less aggressive diseases, such as small lymphocytic lymphoma and follicular lymphoma. In many cases immunophenotyping, particularly analysis of reactivity for CD5 and CD10, is an important adjunct to morphology that usually distinguishes MCL from follicular lymphoma; the former is CD5(+)/CD10(-), whereas follicular lymphoma is the reverse. We report a case of MCL, initially diagnosed as follicular lymphoma, that at presentation expressed neither CD5 nor CD10. At relapse, it was still CD5(-), but CD10 was now detected. Studies for a t(11;14) translocation and CYCLIN D1 protein expression, however, permitted a revised diagnosis of MCL. An MCL with this immunophenotype and classical morphology has not been previously reported.
套细胞淋巴瘤（MCL）是一种预后较差的非霍奇金淋巴瘤，可能会与侵袭性较低的疾病相混淆，如小淋巴细胞淋巴瘤和滤泡性淋巴瘤。在许多情况下，免疫表型分析，特别是对CD5和CD10反应性的分析，是形态学的重要辅助手段，通常可将MCL与滤泡性淋巴瘤区分开来；前者CD5(+) / CD10(-)，而滤泡性淋巴瘤则相反。我们报告一例最初被诊断为滤泡性淋巴瘤的MCL病例，其初诊时既不表达CD5也不表达CD10。复发时，它仍然CD5(-)，但此时检测到了CD10。然而，对t(11;14)易位和细胞周期蛋白D1蛋白表达的研究使得对MCL的诊断得以修正。此前尚未报道过具有这种免疫表型和经典形态的MCL。
