Gopal Purva, Parker John R, Debski Robert, Parker Joseph C
Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Arch Pathol Lab Med. 2008 Aug;132(8):1350-4. doi: 10.5858/2008-132-1350-CPC.
Choroid plexus carcinoma is an uncommon neoplasm of the central nervous system most commonly found in the pediatric population. It is associated with a dismal prognosis, especially if incompletely resected. Accurate histopathologic diagnosis is imperative, and this neoplasm should always be included in the differential diagnosis of a papillary intraventricular tumor. Histopathologic features include blurring of papillary architecture, layers of neoplastic choroid plexus epithelial cells with pleomorphic nuclei, increased nuclear-to-cytoplasmic ratio, increased mitotic activity, areas of necrosis, and brain invasion. Current accepted treatment is gross total surgical resection of the tumor as the goal. Use of adjuvant chemotherapy is controversial at this time; however, it is considered in some cases.
脉络丛癌是一种罕见的中枢神经系统肿瘤，最常见于儿童群体。其预后较差，尤其是在未完全切除的情况下。准确的组织病理学诊断至关重要，并且在鉴别诊断脑室乳头状肿瘤时应始终考虑到这种肿瘤。组织病理学特征包括乳头结构模糊、具有异形核的肿瘤性脉络丛上皮细胞层、核质比增加、有丝分裂活性增加、坏死区域以及脑浸润。目前公认的治疗目标是对肿瘤进行大体全切。此时辅助化疗的使用存在争议；然而，在某些情况下会考虑使用。
