Lee Jonathan L C, Everitt Barry J
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom.
Learn Mem. 2008 Aug 6;15(8):597-602. doi: 10.1101/lm.1029808. Print 2008 Aug.
The theory of memory reconsolidation relates to the hypothesized restabilisation process that occurs following the reactivation of a memory through retrieval. Thus the demonstration of reactivation-dependent amnesia for a previously acquired memory is a prerequisite for showing that such a memory undergoes reconsolidation. Here we show that the appetitive Pavlovian representations that underlie Pavlovian approach and Pavlovian-instrumental transfer are destabilized following their retrieval. This reactivation-dependent amnesia demonstrates that the general motivational or incentive properties of appetitive conditioned stimuli, as well as their conditioned reinforcing properties, can be reduced by blocking memory reconsolidation.
记忆再巩固理论与如下假设的再稳定过程相关，该过程发生在通过提取重新激活记忆之后。因此，对于先前获得的记忆，依赖于重新激活的遗忘症的证明是表明这种记忆经历再巩固的先决条件。在这里，我们表明，构成巴甫洛夫趋近和巴甫洛夫-工具性转移基础的奖赏性巴甫洛夫表征在被提取后会变得不稳定。这种依赖于重新激活的遗忘症表明，通过阻断记忆再巩固，可以降低奖赏性条件刺激的一般动机或激励特性及其条件强化特性。
