School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 3JX, UK.
Psychopharmacology (Berl). 2013 Apr;226(4):649-58. doi: 10.1007/s00213-012-2934-3. Epub 2012 Dec 13.
Discrepancies in an expected outcome have been demonstrated to result in modification of behaviour in both appetitive and aversive conditioning settings.
In this study, we sought to establish whether overexpectation generated from compound conditioning with two previously rewarded stimuli was able to induce memory destabilisation and subsequent reconsolidation in a Pavlovian conditioned approach setting.
It was shown that 4 days, but not 1 day, of overexpectation training was required to induce memory reconsolidation, and this was disrupted by application of the NMDA subtype of glutamate receptor antagonist MK-801 prior to overexpectation training, but not by MK-801 application 6 h post-training.
These data provide evidence that the memories underlying Pavlovian conditioned approach do undergo reconsolidation and that such reconsolidation can be triggered by overexpectation. Therefore, the updating of appetitive conditioned stimulus and unconditioned stimulus associations underpinning conditioned responding in manners other than extinction training is likely achieved through memory reconsolidation.
在预期结果存在差异的情况下，无论是在食欲和厌恶条件作用的环境中，都可以观察到行为的改变。
在这项研究中，我们试图确定，通过两个以前奖励过的刺激进行复合条件作用产生的过度期望，是否能够在巴甫洛夫条件作用的接近环境中诱导记忆不稳定和随后的再巩固。
结果表明，需要 4 天而不是 1 天的过度期望训练才能诱导记忆再巩固，并且在过度期望训练之前应用 NMDA 型谷氨酸受体拮抗剂 MK-801 会破坏这种再巩固，但在训练后 6 小时应用 MK-801 则不会。
这些数据提供了证据表明，巴甫洛夫条件作用的接近记忆确实会经历再巩固，并且这种再巩固可以通过过度期望来触发。因此，在除了消退训练之外的其他方式下，更新与条件刺激和非条件刺激相关的食欲条件反射记忆，可能是通过记忆再巩固来实现的。
