Oliveto A H, Hughes J R, Terry S Y, Bickel W K, Higgins S T, Pepper S L, Fenwick J W
Department of Psychiatry, University of Vermont, Burlington 05401.
Clin Pharmacol Ther. 1991 Aug;50(2):157-64. doi: 10.1038/clpt.1991.120.
Smoking cessation increases caffeine blood levels, and this has been hypothesized to cause some of the symptoms of tobacco withdrawal (e.g., anxiety and insomnia). To test this hypothesis, 10 coffee drinkers who smoked cigarettes were entered into a completely within-subjects experimental design in which the effects of caffeine dose (0, 50, and 100 mg/coffee serving) and smoking status (smoking versus abstinence) were examined over a 4-day period. Self-reported and observed measures of tobacco withdrawal, caffeine withdrawal, and intoxication, as well as psychomotor tasks and vital signs, were completed daily; blood was drawn at the end of each period. Temporary abstinence produced typical withdrawal symptoms but did not significantly increase caffeine blood levels. Caffeine did not increase the severity of symptoms but did decrease the severity of withdrawal-induced hunger. These findings suggest that, in the absence of increased blood levels, caffeine does not increase the severity of tobacco withdrawal.
戒烟会提高血液中的咖啡因水平，据推测，这会导致一些戒烟症状（如焦虑和失眠）。为了验证这一假设，10名喝咖啡的吸烟者参与了一项完全被试内实验设计，该实验在4天内考察了咖啡因剂量（0、50和100毫克/杯咖啡）和吸烟状态（吸烟与戒烟）的影响。每天完成关于戒烟、咖啡因戒断和中毒的自我报告及观察指标，以及心理运动任务和生命体征；在每个阶段结束时采集血液样本。暂时戒烟产生了典型的戒断症状，但并未显著提高血液中的咖啡因水平。咖啡因并未增加症状的严重程度，但确实减轻了戒断引起的饥饿严重程度。这些发现表明，在血液水平未升高的情况下，咖啡因不会增加戒烟症状的严重程度。
