在单个连续微反应器序列中快速多步合成1,2,4-恶二唑。
Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.
作者信息
Grant Daniel, Dahl Russell, Cosford Nicholas D P
机构信息
The San Diego Center for Chemical Genomics, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, Califoria 92037, USA.
出版信息
J Org Chem. 2008 Sep 19;73(18):7219-23. doi: 10.1021/jo801152c. Epub 2008 Aug 8.
Abstract
A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.
摘要
描述了一种在单个连续微反应器序列中由易得的芳基腈和活性羰基化合物合成双取代1,2,4-恶二唑的通用方法。该合成过程采用三个连续的微反应器，在约30分钟内生成1,2,4-恶二唑，其产量（40 - 80毫克）足以进行全面表征并快速供应文库。
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