用于药物发现与开发的微流控技术：从靶点选择到产品生命周期管理
Microfluidics for drug discovery and development: from target selection to product lifecycle management.
作者信息
Kang Lifeng, Chung Bong Geun, Langer Robert, Khademhosseini Ali
机构信息
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Drug Discov Today. 2008 Jan;13(1-2):1-13. doi: 10.1016/j.drudis.2007.10.003. Epub 2007 Nov 26.
Abstract
Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies and product management.
摘要
微流控技术具备将分析检测小型化并提高实验通量的能力，这在药物发现和开发领域引起了极大的关注。这些特性使微流控系统成为许多药物发现和开发应用中潜在的有价值工具。在此，我们回顾了用于药物发现和开发的微流控装置的最新进展，并强调了它们在该过程不同阶段的应用，包括靶点选择、先导化合物识别、临床前测试、临床试验、化学合成、制剂研究和产品管理。
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