Borisov Alexander V, Detistov Oleksandr S, Pukhovaya Viktoria I, Zhuravel' Irina O, Kovalenko Sergiy M
National University of Pharmacy, Pushkinska str.53, 61002 Kharkiv, Ukraine.
J Comb Chem. 2009 Nov-Dec;11(6):1023-9. doi: 10.1021/cc900070m.
Combinatorial libraries of substituted 3-(methylthio)-5-(amino)-4-([1,2,4]oxadiazol-5-yl)-1H-pyrazoles 6, 10, 13, 15 (395 members, yields 32-87%), 4-([1,2,4]oxadiazol-5-yl)-1H-3,5-pyrazolediamines 8, 11 (571 members, yields 25-83%), 2-(methylthio)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 17 (85 members, yields 56-95%), and 2-(amino)-3-([1,2,4]oxadiazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-ones 18 (110 members, yields 56-95%) were synthesized by the parallel liquid-phase synthesis method.
通过平行液相合成法合成了取代的3-(甲硫基)-5-(氨基)-4-([1,2,4]恶二唑-5-基)-1H-吡唑6、10、13、15（395个成员，产率32 - 87%）、4-([1,2,4]恶二唑-5-基)-1H-3,5-吡唑二胺8、11（571个成员，产率25 - 83%）、2-(甲硫基)-3-([1,2,4]恶二唑-5-基)吡唑并[1,5-a]嘧啶-7(4H)-酮17（85个成员，产率56 - 95%）以及2-(氨基)-3-([1,2,4]恶二唑-5-基)吡唑并[1,5-a]嘧啶-7(4H)-酮18（110个成员，产率56 - 95%）的组合库。
