Colgin Laura Lee, Moser Edvard I, Moser May-Britt
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Trends Neurosci. 2008 Sep;31(9):469-77. doi: 10.1016/j.tins.2008.06.008. Epub 2008 Aug 5.
Memory interference is a common cause of forgetting. Interference is a byproduct of the need to balance the formation of well-differentiated representations against the ability to retrieve memories from cues that are not identical to the original experience. How the brain accomplishes this has remained elusive. Here we review how insights can be gained from studies of an apparently unrelated phenomenon in the rodent brain--remapping in hippocampal place cells. Remapping refers to the formation of distinct representations in populations of place cells after minor changes in inputs to the hippocampus. Remapping might reflect processes involved generally in decorrelation of overlapping signals. These processes might be crucial for storing large numbers of similar experiences with only minimal interference.
记忆干扰是遗忘的常见原因。干扰是在平衡形成清晰分化的表征与从与原始体验不同的线索中检索记忆的能力时产生的副产品。大脑如何完成这一过程仍然难以捉摸。在这里，我们回顾如何从对啮齿动物大脑中一个明显不相关的现象——海马体位置细胞的重映射研究中获得见解。重映射是指海马体输入发生微小变化后，位置细胞群体中形成不同的表征。重映射可能反映了通常参与重叠信号去相关的过程。这些过程对于存储大量相似经历且干扰最小可能至关重要。
