Wanjia Guo, Han Subin, Kuhl Brice A
Department of Psychology, University of Oregon, 1451 Onyx St., Eugene, OR 97403, USA; Institute of Neuroscience, University of Oregon, 1585 E 13th Ave., Eugene, OR 97403, USA.
Department of Psychology, University of Virginia, Gilmer Hall, 485 McCormick Rd., Charlottesville, VA 22904, USA.
Curr Biol. 2025 Jun 23;35(12):2893-2902.e5. doi: 10.1016/j.cub.2025.05.029. Epub 2025 Jun 3.
Recent human neuroimaging studies of episodic memory have revealed a counterintuitive phenomenon in the hippocampus: when events are highly similar, corresponding hippocampal activity patterns are sometimes less correlated than activity patterns associated with unrelated events. This phenomenon-repulsion-is not accounted for by most theories of the hippocampus, and the conditions that trigger repulsion remain poorly understood. Here, we used a spatial route-learning task and high-resolution fMRI in humans to test whether hippocampal repulsion is fundamentally driven by internal beliefs about the environment. By precisely measuring participants' internal beliefs and actively manipulating them, we show that repulsion selectively occurred in hippocampal subfields CA3 and dentate gyrus when visual input was ambiguous-or even identical-but internal beliefs were distinct. These findings firmly establish conditions that elicit repulsion and have broad relevance to theories of hippocampal function and to the fields of human episodic memory and rodent spatial navigation.
当事件高度相似时，相应的海马体活动模式有时比与不相关事件相关的活动模式相关性更低。这种现象——排斥——在大多数海马体理论中都没有得到解释，引发排斥的条件仍然知之甚少。在这里，我们使用空间路线学习任务和高分辨率功能磁共振成像对人类进行测试，以检验海马体排斥是否从根本上由对环境的内在信念驱动。通过精确测量参与者的内在信念并积极加以操控，我们发现，当视觉输入模糊不清——甚至完全相同——但内在信念不同时，排斥会选择性地出现在海马体子区域CA3和齿状回中。这些发现明确了引发排斥的条件，对海马体功能理论以及人类情景记忆和啮齿动物空间导航领域具有广泛的相关性。
