Frohlich Luiz Felipe, Vieira Paulo J C, Teixeira Paulo José Zimermann, Silva Fernando Abreu, Ribeiro Jorge P, Berton Danilo C
Postgraduate Studies Program in Pulmonology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Pediatr Pulmonol. 2014 Sep;49(9):911-8. doi: 10.1002/ppul.22929. Epub 2013 Dec 23.
Post-infectious bronchiolitis obliterans (PBO) is a chronic lung disease characterized by the persistence of continuous obstructive respiratory symptoms following an acute and severe respiratory infection in children under 3 years old. The purpose of the present study was to investigate if adolescents and adults with diagnosis of PBO have reduced aerobic capacity and identify factors related with exercise performance.
A convenience sample of 16 patients (10-23 years) that have consulted with established diagnosis of PBO in a tertiary care clinic were studied. Fourteen healthy matched subjects were selected from the community to serve as controls. They performed resting lung function tests and cycle incremental cardiopulmonary exercise tests.
Peak aerobic capacity (peak V˙O(2)) was significantly lower in patients compared to controls (84 ± 15 vs. 101 ± 17% pred; P < 0.01). Peak V˙O(2) was correlated with rest inspiratory capacity (IC) (r = 0.60; P = 0.02) and marginally with forced expiratory volume in the first second (FEV(1)) (r = 0.45; P = 0.09). Additionally, FEV(1) was correlated with IC (r = 0.83; P < 0.01) and residual volume/total lung capacity (r = -0.91, P < 0.01).
Adolescent and adult patients with PBO had reduced peak V˙O(2) compared to healthy controls. Peak V˙O(2) was correlated with parameters of airflow limitation and rest hyperinflation. The greater the air flow limitation (lower FEV(1)) the greater the hyperinflation, air trapping, and aerobic capacity reduction.
感染后闭塞性细支气管炎（PBO）是一种慢性肺部疾病，其特征为3岁以下儿童在急性重症呼吸道感染后持续存在持续性阻塞性呼吸症状。本研究的目的是调查诊断为PBO的青少年和成年人是否有氧能力下降，并确定与运动表现相关的因素。
研究了在三级医疗诊所就诊且已确诊为PBO的16例患者（10 - 23岁）的便利样本。从社区中选取14名健康匹配的受试者作为对照。他们进行了静息肺功能测试和递增式心肺运动测试。
与对照组相比，患者的峰值有氧能力（峰值V˙O(2)）显著降低（84±15 vs. 101±17%预计值；P < 0.01）。峰值V˙O(2)与静息吸气量（IC）相关（r = 0.60；P = 0.02），与第一秒用力呼气量（FEV(1)）呈边缘相关（r = 0.45；P = 0.09）。此外，FEV(1)与IC相关（r = 0.83；P < 0.01），与残气量/肺总量相关（r = -0.91，P < 0.01）。
与健康对照组相比，PBO青少年和成年患者的峰值V˙O(2)降低。峰值V˙O(2)与气流受限和静息肺过度充气参数相关。气流受限越大（FEV(1)越低），肺过度充气、气体潴留和有氧能力降低越明显。
