糖皮质激素与环磷酰胺联合治疗后出现的Churg-Strauss综合征中的隐匿性回肠动脉动脉瘤。

Repressed ileal artery aneurysms in Churg-Strauss syndrome following combination treatment with glucocorticoid and cyclophosphamide.

作者信息

Yamasaki Akira, Tomita Katsuyuki, Fujii Yoshihiro, Hasegawa Yasuyuki, Watanabe Masanari, Sano Hiroyuki, Okazaki Ryota, Ouchi Yasufumi, Nakamura Seiichi, Shimizu Eiji

机构信息

Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori, 683-8504, Japan.

出版信息

Rheumatol Int. 2009 Jan;29(3):335-7. doi: 10.1007/s00296-008-0668-7. Epub 2008 Aug 8.

DOI:10.1007/s00296-008-0668-7

PMID:18688614

Abstract

Churg-Strauss syndrome (CSS) is a systemic small-vessel vasculitis characterized by asthma and eosinophilia. We report a case of CSS complicated by multiple aneurysms in the small intestine. A 57-year-old man was admitted to our hospital with fever and blood eosinophilila. During admission, aneurysms in his small intestine ruptured and partial resection of the small intestine was required. After combination therapy of glucocorticoid (GC) and cyclophosphamide (CYC) for 6 months, aneurysms in the small intestine disappeared. The gastrointestinal involvements usually result in poor prognosis in CSS. However, combination therapy of GC and CYC might be effective for remission of aneurysms caused by small vessel vasculitis.

摘要

变应性肉芽肿性血管炎（CSS）是一种以哮喘和嗜酸性粒细胞增多为特征的系统性小血管炎。我们报告一例合并小肠多发动脉瘤的CSS病例。一名57岁男性因发热和血液嗜酸性粒细胞增多入住我院。住院期间，他的小肠动脉瘤破裂，需要进行小肠部分切除术。在糖皮质激素（GC）和环磷酰胺（CYC）联合治疗6个月后，小肠动脉瘤消失。CSS患者的胃肠道受累通常预后较差。然而，GC和CYC联合治疗可能对缓解小血管炎引起的动脉瘤有效。