Nilsson-Ehle H, Jagenburg R, Landahl S, Lindstedt S, Svanborg A, Westin J
Department of Medicine, Ostra Hospital, University of Göteborg, Sweden.
Eur J Haematol. 1991 Jul;47(1):10-6. doi: 10.1111/j.1600-0609.1991.tb00555.x.
In a representative population sample (n = 973) born 1901-1902 and examined at the ages of 70, 75, 79, and 81, the change in serum cobalamins with increasing age was studied by trend analysis using values obtained in single individuals at all four examinations. In subsamples without definable disorders, the mean annual decline was: among men 3.4 pmol/l (p less than 0.05), among women 3.2 pmol/l (n.s.). The decline was possibly more pronounced among individuals with low and intermediate concentrations. The health-related lower reference limits (the 2.5 percentile values of subsamples without definable disorders) did not differ significantly between sexes and age groups, but low concentrations or ongoing cobalamin medication became more common with advancing age. The results indicate a slight fall in serum cobalamins between age 70 and 81 but do not call for age-related lower reference limits.
在一个具有代表性的出生于1901年至1902年的人群样本（n = 973）中，分别在70岁、75岁、79岁和81岁时进行检查，通过趋势分析，利用所有四次检查中个体获得的值，研究了血清钴胺素随年龄增长的变化。在无明确疾病的子样本中，年平均下降幅度为：男性为3.4 pmol/l（p<0.05），女性为3.2 pmol/l（无统计学意义）。在钴胺素浓度低和中等的个体中，下降可能更明显。与健康相关的较低参考限值（无明确疾病的子样本的第2.5百分位数）在性别和年龄组之间没有显著差异，但随着年龄的增长，低浓度或正在服用钴胺素药物的情况变得更为常见。结果表明，70岁至81岁之间血清钴胺素略有下降，但并不需要与年龄相关的较低参考限值。
