佩鲁香豆素，一种由铜绿假单胞菌的pvc基因簇产生的新代谢产物。
Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa.
作者信息
Clarke-Pearson Michael F, Brady Sean F
机构信息
Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
J Bacteriol. 2008 Oct;190(20):6927-30. doi: 10.1128/JB.00801-08. Epub 2008 Aug 8.
Abstract
The pvc gene cluster from Pseudomonas aeruginosa has been linked to the biosynthesis of both the pyoverdine chromophore and pseudoverdine. Our reinvestigation of the role this gene cluster plays in P. aeruginosa secondary metabolite biosynthesis shows that its major product is actually paerucumarin, a novel isonitrile functionalized cumarin.
摘要
铜绿假单胞菌的pvc基因簇与绿脓菌素发色团和假绿脓菌素的生物合成均有关联。我们对该基因簇在铜绿假单胞菌次级代谢产物生物合成中所起作用的重新研究表明，其主要产物实际上是paerucumarin，一种新型的异腈官能化香豆素。
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