Ambrosi Cecilia, Leoni Livia, Visca Paolo
Unità di Microbiologia Molecolare, I.R.C.C.S. Lazzaro Spallanzani, 00149 Rome, Italy.
Appl Environ Microbiol. 2002 Aug;68(8):4122-6. doi: 10.1128/AEM.68.8.4122-4126.2002.
We investigated the regulation of the psbA and pvdA pyoverdine biosynthesis genes, which encode the L-ornithine N(5)-oxygenase homologues in Pseudomonas strain B10 and Pseudomonas aeruginosa PAO1, respectively. We demonstrate that pyoverdine(B10), as the end product of its biosynthetic pathway, is a key participant of the control circuit regulating its own production in Pseudomonas strain B10. In P. aeruginosa PAO1, however, pyoverdine(PAO1) has no apparent role in the positive regulation of the pvdA gene.
我们研究了绿脓菌素生物合成基因psbA和pvdA的调控,它们分别在假单胞菌菌株B10和铜绿假单胞菌PAO1中编码L-鸟氨酸N(5)-加氧酶同源物。我们证明,作为其生物合成途径的终产物,绿脓菌素(B10)是假单胞菌菌株B10中调控自身产生的控制回路的关键参与者。然而,在铜绿假单胞菌PAO1中,绿脓菌素(PAO1)在pvdA基因的正调控中没有明显作用。