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对异腈基团生物合成及其机制的当前理解。

Current Understanding toward Isonitrile Group Biosynthesis and Mechanism.

作者信息

Chen Tzu-Yu, Chen Jinfeng, Tang Yijie, Zhou Jiahai, Guo Yisong, Chang Wei-Chen

机构信息

Department of Chemistry, North Carolina State University Raleigh, NC 27695, U.S.A.

State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.

出版信息

Chin J Chem. 2021 Feb;39(2):463-472. doi: 10.1002/cjoc.202000448. Epub 2020 Sep 24.

DOI:10.1002/cjoc.202000448
PMID:34658601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8519408/
Abstract

Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.

摘要

异腈基团已在许多天然产物中被鉴定出来。由于N≡C三键具有广泛的反应活性，这些天然产物具有宝贵的药用潜力。本综述总结了目前负责含异腈天然产物生成的生物合成途径及相应的酶。基于所采用的策略，讨论了两种根本不同的方法。此外，还介绍了在阐明异腈基团形成机制方面的最新进展。

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