催产素和8-L-赖氨酸加压素对组胺引起收缩的豚鼠和人离体胆囊条的松弛作用。

Relaxant effects of oxytocin and 8-l-lysine-vasopressin on guinea pig and human gallbladder strips in vitro contracted by histamine.

作者信息

Janković S, Beleslin D

机构信息

Department of Pharmacology, Medical Faculty of Kragujevac, Yugoslavia.

出版信息

Digestion. 1991;48(1):18-24. doi: 10.1159/000200659.

DOI:10.1159/000200659

PMID:1868965

Abstract

Both human and guinea pig gallbladder strips were tonically contracted by supramaximal concentrations of histamine in vitro. Guinea pig gallbladder strips were also tonically contracted by potassium, with no spontaneous relaxation after 5 min. The amplitude of the contractions caused by histamine decreased spontaneously only by 34 +/- (SD) 10% after 5 min in guinea pig strips and by 25 +/- 7% after 5 min in human strips. Both oxytocin and 8-l-lysine-vasopressin dose-dependently relaxed almost completely contractions caused by histamine and potassium in guinea pigs. In humans, only 8-l-lysine-vasopressin decreased the amplitude of histamine contractions. In both species, neither oxytocin nor 8-l-lysine-vasopressin affected the basal tone of strips.

摘要

在体外，组胺的超最大浓度可使人类和豚鼠的胆囊条发生张力性收缩。钾离子也可使豚鼠胆囊条发生张力性收缩，5分钟后无自发松弛。组胺引起的收缩幅度在豚鼠胆囊条中5分钟后仅自发降低34±（标准差）10%，在人类胆囊条中5分钟后降低25±7%。催产素和8-L-赖氨酸加压素均剂量依赖性地使豚鼠由组胺和钾引起的收缩几乎完全松弛。在人类中，只有8-L-赖氨酸加压素降低了组胺收缩的幅度。在这两个物种中，催产素和8-L-赖氨酸加压素均不影响胆囊条的基础张力。