抗坏血酸在2,2'-[3,6-二氧杂-1,8-辛烷二基双（亚氨乙基）]-双对苯二酚碳糊电极上的电化学行为
Electrochemical behavior of ascorbic acid at a 2,2'-[3,6-Dioxa-1,8-octanediylbis(nitriloethylidyne)]-bis-hydroquinone carbon paste electrode.
作者信息
Taleat Zahra, Mazloum Ardakani Mohammad, Naeimi Hossein, Beitollahi Hadi, Nejati Maryam, Reza Zare Hamid
机构信息
Department of Chemistry, Faculty of Science, Yazd University, Iran.
出版信息
Anal Sci. 2008 Aug;24(8):1039-44. doi: 10.2116/analsci.24.1039.
Electrocatalytic oxidation of ascorbic acid (AA) at a carbon paste electrode, chemically modified 2,2'-[3,6-dioxa-1,8-octanediylbis(nitriloethylidyne)]-bis-hydroquinone, was thoroughly investigated. The results of cyclic voltammetry, double potential-step chronoamperometry, linear sweep voltammetry and differential pulse voltammetry (DPV) studies were used for the prediction of the mechanism of electrochemical oxidation of AA mediated with 2,2'-[3,6-dioxa-1,8-octanediylbis(nitriloethylidyne)]-bis-hydroquinone at the surface of the modified electrode. The diffusion coefficient (D = 2.45 x 10(-5) cm(2) s(-1)) and the kinetic parameters such as the electron transfer coefficient (alpha = 0.34) were also determined. The results of DPV using the 2,2'-[3,6-dioxa-1,8-octanediylbis(nitriloethylidyne)]-bis-hydroquinone-modified electrode were applied in a highly sensitive determination of AA in drug samples. A linear range of 3.0 x 10(-6) - 1.2 x 10(-4) M and the detection limit (3sigma) 3.8 x 10(-7) M were obtained for DPV determination of AA in buffered pH 7.00 solutions (0.1 M phosphate buffer).
对在化学修饰的2,2'-[3,6-二氧杂-1,8-辛烷二基双（次氮基亚乙基）]-双对苯二酚碳糊电极上抗坏血酸（AA）的电催化氧化进行了深入研究。循环伏安法、双电位阶跃计时电流法、线性扫描伏安法和差分脉冲伏安法（DPV）研究的结果用于预测2,2'-[3,6-二氧杂-1,8-辛烷二基双（次氮基亚乙基）]-双对苯二酚介导的AA在修饰电极表面的电化学氧化机理。还测定了扩散系数（D = 2.45×10⁻⁵ cm² s⁻¹）和诸如电子转移系数（α = 0.34）等动力学参数。使用2,2'-[3,6-二氧杂-1,8-辛烷二基双（次氮基亚乙基）]-双对苯二酚修饰电极的DPV结果应用于药物样品中AA的高灵敏度测定。在pH 7.00的缓冲溶液（0.1 M磷酸盐缓冲液）中对AA进行DPV测定时，获得了3.0×10⁻⁶ - 1.2×10⁻⁴ M的线性范围和3.8×10⁻⁷ M的检测限（3σ）。
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