Cronin A J, Claffey N, Stassen L F
Periodontology, Dublin Dental School and Hospital, Lincoln Place, Dublin 2, Ireland.
Br Dent J. 2008 Aug 9;205(3):131-7. doi: 10.1038/sj.bdj.2008.653.
The use of odds ratio (OR) in risk analysis is considered a useful means of cross-comparing risk factors by which a disease is influenced. This article outlines the interpretation of reported ORs with respect to periodontal disease, highlighting those factors that are most deserving of consideration. The claim that periodontal disease is implicated in some serious systemic diseases is investigated with respect to the evidence. Data retrieval was carried out, focusing primarily on ORs for factors shown to be positively correlated with the incidence of periodontal disease. Using the available data, a risk evaluation scoring system was proposed (the Cronin/Stassen BEDS CHASM scale). The results of the evaluation support the view that hygiene therapy, smoking cessation and control of the glycaemic state offer the largest and most easily achieved reduction in risk with respect to attachment loss. The literature on systemic diseases indicates that the mechanisms with which periodontitis may interact seem biologically plausible, compellingly so in the cases of coronary heart disease and diabetes mellitus. However, statistical evidence to confirm these suggested interactions is equivocal, with the data retrieved in some instances being less than decisive. Further investigation is recommended.
在风险分析中使用比值比（OR）被认为是交叉比较影响疾病的风险因素的一种有用方法。本文概述了与牙周病相关的已报道比值比的解读，突出了那些最值得考虑的因素。关于牙周病与某些严重全身性疾病有关的说法，本文根据证据进行了调查。主要针对显示与牙周病发病率呈正相关的因素的比值比进行了数据检索。利用现有数据，提出了一种风险评估评分系统（克罗宁/斯塔森BEDS CHASM量表）。评估结果支持这样一种观点，即就附着丧失而言，口腔卫生治疗、戒烟和控制血糖状态能最大程度且最容易地降低风险。关于全身性疾病的文献表明，牙周炎可能与之相互作用的机制在生物学上似乎是合理的，在冠心病和糖尿病的情况下尤其如此。然而，证实这些潜在相互作用的统计证据并不明确，在某些情况下检索到的数据并不具有决定性。建议进一步开展研究。
