Al-Amoudi Saeed M
Department of Pathology, King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2008 Aug;29(8):1192-3.
Low leukocyte count secondary to leukocyte aggregation caused by an ethylene diamine tetra acetic acid (EDTA) occur in both benign and malignant disorders. We report a 71-year-old male patient who was admitted to the hospital with acute chest infection. Complete blood count (CBC) collected in EDTA tube and analyzed by sysmex instrument SE/9500 revealed low hemoglobin level of 9.4g/dl, white blood cell (WBC) count of 8.2x109/L and neutrophils of 4.8x109/L. Peripheral blood smear review shows multiple leukocytes aggregation one clump in each field. When we ask for another blood sample in citrate anticoagulant, the CBC showed WBC count of 11.8x109/L and neutrophils of 6.26 x 109/L. This is a case of low leukocyte count secondary to leukocyte aggregation induced by EDTA.
由乙二胺四乙酸（EDTA）引起的白细胞聚集导致的低白细胞计数在良性和恶性疾病中均有发生。我们报告了一名71岁男性患者，他因急性胸部感染入院。用EDTA管采集全血细胞计数（CBC）并通过Sysmex SE/9500仪器分析，结果显示血红蛋白水平低至9.4g/dl，白细胞（WBC）计数为8.2×10⁹/L，中性粒细胞为4.8×10⁹/L。外周血涂片检查显示每个视野中有多个白细胞聚集形成一团。当我们要求用柠檬酸盐抗凝剂采集另一份血样时，CBC显示白细胞计数为11.8×10⁹/L，中性粒细胞为6.26×10⁹/L。这是一例由EDTA诱导的白细胞聚集导致的低白细胞计数病例。
