Goebbels M, Spitznas M
Universitäts-Augenklinik, Bonn, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1991;229(3):254-7. doi: 10.1007/BF00167879.
In all, 21 diabetic and 23 non-diabetic patients underwent endothelial fluorophotometry before and at 4 days, 3 weeks and 6 weeks after phacoemulsification with posterior chamber intraocular lens (IOL: PMMA) implantation. After topical fluorescein instillation, fluorophotometry was performed using an automated computerized fluorophotometer. The aim of this study was to assess early postoperative endothelial damage quantitatively and to detect possible differences between diabetic and non-diabetic patients in that regard. Preoperatively, the endothelial permeability of diabetic patients did not differ from that of non-diabetic individuals (P = 0.5). At 4 days after phacoemulsification with posterior chamber IOL implantation, endothelial permeability was significantly increased in both groups (P less than 0.001), but significantly more so in diabetic patients (P less than 0.001). The endothelial barrier function had fully recovered 3 weeks after surgery in non-diabetic subjects and 6 weeks after surgery in diabetic patients as well.
总共有21名糖尿病患者和23名非糖尿病患者在植入后房型人工晶状体（IOL：PMMA）的超声乳化术前以及术后4天、3周和6周接受了内皮荧光光度测定。在局部滴注荧光素后，使用自动计算机化荧光光度计进行荧光光度测定。本研究的目的是定量评估术后早期的内皮损伤，并检测糖尿病患者和非糖尿病患者在这方面的可能差异。术前，糖尿病患者的内皮通透性与非糖尿病个体无差异（P = 0.5）。在植入后房型人工晶状体的超声乳化术后4天，两组的内皮通透性均显著增加（P < 0.001），但糖尿病患者增加得更为显著（P < 0.001）。非糖尿病受试者术后3周内皮屏障功能完全恢复，糖尿病患者术后6周内皮屏障功能也完全恢复。
