Bourne W M, Brubaker R F
Ophthalmology. 1982 Jun;89(6):591-5. doi: 10.1016/s0161-6420(82)34745-4.
Five patients with the iridocorneal endothelial (ICE) syndrome were examined by fluorophotometry. All patients had typical abnormal corneal endothelium, peripheral anterior synechiae, and distortion of the iris (pupillary irregularity or anterior stromal traction tears) in one eye only. Fluorescein was deposited in the superior cornea of both eyes by iontophoresis, and the cornea and anterior chamber concentrations and total mass of fluorescein were measured hourly over the ensuing eight hours. In all five patients, the endothelial permeability to fluorescein was within normal limits in the normal eye. In four of the five abnormal eyes, endothelial permeability was markedly decreased. In these four patients, the permeability to fluorescein in the normal eye was approximately six times that in the abnormal eye. In the fifth patient, the endothelial permeability was normal in both eyes. The central corneal thicknesses were normal in both eyes of all five patients. These results indicate that in many eyes with the ICE syndrome, corneal endothelial permeability to solutes is markedly decreased. Decreased endothelial permeability to solutes has not been documented previously in any clinical corneal disorder and may be of importance in the pathophysiologic changes that accompany endothelial disease.
对5例虹膜角膜内皮（ICE）综合征患者进行了荧光光度测定。所有患者仅一只眼睛有典型的异常角膜内皮、周边前粘连和虹膜变形（瞳孔不规则或前基质牵引性撕裂）。通过离子电渗疗法将荧光素沉积在双眼的上角膜，随后8小时内每小时测量荧光素在角膜和前房的浓度以及荧光素的总量。在所有5例患者中，正常眼的内皮对荧光素的通透性在正常范围内。在5只异常眼中的4只，内皮通透性明显降低。在这4例患者中，正常眼对荧光素的通透性约为异常眼的6倍。在第5例患者中，双眼的内皮通透性均正常。所有5例患者双眼的中央角膜厚度均正常。这些结果表明，在许多ICE综合征患者的眼中，角膜内皮对溶质的通透性明显降低。溶质内皮通透性降低在以往任何临床角膜疾病中均未被记录，可能在伴随内皮疾病的病理生理变化中具有重要意义。
