四氯化钛/三乙胺促进的芳香杂环、醛和活性亚甲基化合物之间的三组分缩合反应。
TiCl4/Et3N-promoted three-component condensation between aromatic heterocycles, aldehydes, and active methylene compounds.
作者信息
Renzetti Andrea, Dardennes Emmanuel, Fontana Antonella, De Maria Paolo, Sapi Janos, Gérard Stéphane
机构信息
Institut de Chimie Moléculaire de Reims, UMR CNRS 6229, Université de Reims-Champagne-Ardenne, Faculté de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims, Cedex, France.
出版信息
J Org Chem. 2008 Sep 5;73(17):6824-7. doi: 10.1021/jo800529q. Epub 2008 Aug 9.
PMID:18690741
Abstract
A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl4/Et3N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.
摘要
报道了一种通过TiCl4/Et3N促进醛、吲哚杂环和各种活性羰基化合物的三分子缩合反应来合成多官能化吲哚衍生物的一锅法。还描述了这些反应的原理及对其他杂环体系的拓展。
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