N-杂环卡宾催化烯烃与芳香醛的区域选择性氧化羰酯化：α-烷氧基酮和酯的高产率合成。
N-heterocyclic carbene catalyzed regioselective oxo-acyloxylation of alkenes with aromatic aldehydes: a high yield synthesis of α-acyloxy ketones and esters.
机构信息
Chemical Engineering and Process Development Division, National Chemical Laboratory (CSIR), Pashan Road, Pune, 411008, India.
出版信息
Org Biomol Chem. 2013 Oct 14;11(38):6477-82. doi: 10.1039/c3ob41551a. Epub 2013 Aug 22.
PMID:23969565
Abstract
An N-heterocyclic carbene (NHC)-catalyzed reaction of alkenes with aromatic aldehydes providing for a high yield synthesis of α-acyloxy ketones and esters has been described. This unprecedented regioselective oxidative process employs NBS and Et3N in stoichiometric amounts and O2 (1 atm) as an oxidant under ambient conditions in DMSO as a solvent.
摘要
已描述了 N-杂环卡宾（NHC）催化的烯烃与芳醛的反应，可高收率合成α-烷氧基酮和酯。这种前所未有的区域选择性氧化过程在 DMSO 作为溶剂的条件下，使用 NBS 和 Et3N（化学计量）和 O2（1 大气压）作为氧化剂，在环境条件下进行。
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