由二氯甲基甲醚和四氯化钛介导的富电子芳香环的甲酰化反应：范围与局限性

Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: scope and limitations.

作者信息

Ramos-Tomillero Iván, Paradís-Bas Marta, de Pinho Ribeiro Moreira Ibério, Bofill Josep María, Nicolás Ernesto, Albericio Fernando

机构信息

Institute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain.

Deparment of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain.

出版信息

Molecules. 2015 Mar 26;20(4):5409-22. doi: 10.3390/molecules20045409.

DOI:10.3390/molecules20045409

PMID:25822080

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6272369/

Abstract

Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.

摘要

在此，我们研究了由本研究小组先前描述的四氯化钛和二氯甲基甲醚介导的芳香族甲酰化反应，该反应适用于包括苯酚、甲氧基苯和甲基苯在内的多种芳香环，是制备芳香醛的一种出色方法。我们在此确定，该过程的区域选择性通过芳香部分中的原子与金属核中的原子之间的配位作用得到了极大的促进。